IVF treatment in younger women may increase chance of breast cancer

IVF treatment in younger women dramatically increases their chance of developing breast cancer later in life, research suggests. Women who started taking fertility drugs and went through IVF around their 24th birthday were found to have a 56 per cent greater chance of developing breast cancer than those in the same age group who went through treatments without IVF. But there was no increased risk for women who started fertility treatments when they were about 40 years old, regardless of whether they had IVF or not, according to the Australian study The researchers said: 'For younger women there is some cause for concern, because it appears that they may face an increased risk of breast cancer after IVF treatment.' The findings were based on a study of more than 21,000 women and published in the journal Fertility and Sterility. Study author Louise Stewart from the University of Western Australia said younger women might see an increased risk of breast cancer because they are exposed to higher levels of circulating estrogen during their cycles of IVF treatment. In the UK 45,264 women had IVF treatment in 2010. A third of women under 35 successfully had a child as a result However, she added: 'I don't think it's a huge increased risk that you should worry or panic (about).' The researchers collected information on 21,025 women between the ages of 20 and 40 who went through fertility treatment at the hospitals of Western Australia between 1983 and 2002. They were able to piece together enough data to follow the women for some 16 years to see if they developed breast cancer. Roughly 1.7 per cent of the 13,644 women who only used fertility drugs without IVF ended up developing breast cancer by the end of the study. That figure was about two percent for women who used fertility drugs and underwent IVF - a difference that researchers said wasn't statistically significant. This changed when women were divided into different age groups, with women aged 24 about one-and-a-half times more likely to develop breast cancer if they had IVF alongside other fertility treatments. However, Stewart said they couldn't yet say that IVF was causing the increased cancer risk in younger women, as these women could be different in some significant way from those who only have other types of fertility treatment. 'If for example, younger women who had IVF were more likely to have a specific cause of infertility, and this was related to an increased risk of breast cancer, then it would appear that IVF was related to breast cancer when in fact it was the type of infertility that was more common in women who had IVF,' she said. Linda Giudice, president-elect of the American Society of Reproductive Medicine, added: 'The development of breast cancer is linked to estrogen exposure and the longer one is exposed, the greater the risk. 'In an IVF cycle there is a short, but significant elevation in circulating estrogen, and whether this is linked to the observations found in the study is not clear at this time.' The researchers said the study results would reassure women who start IVF treatment in their 30s and 40s. However, they added: 'Women should be aware that delivering their first child late in reproductive life, whether assisted by IVF or not, is associated with an increased risk of breast cancer.' Statistically, younger women have a greater chance of successfully having a baby following IVF. They suggested a follow-up study of women who undergo a greater range of cycles to see if there's a connection between IVF 'dose' and breast cancer rate. Article: 25th June 2012 www.dailymail.co.uk

61 year old IVF mum said 'I was too old when I had my baby'

A retired teacher who gave birth at 57 through IVF now admits that she was too old to have a child. Susan Tollefsen sparked an ethical storm after becoming Britain’s oldest first-time mother when she had daughter Freya using sperm from her partner Nick Mayer, who is 11 years her junior, and a donor egg.
Now aged 61 and separated from Mr Mayer, she believes there should be an age limit of 50 for IVF treatment for women in the UK. The pensioner said she had split from Mr Mayer in part because of the ‘shock’ of having a child so late in life.

She said: ‘Freya is without doubt the best thing I have ever done in my life, and I have no regrets. But with the benefit of hindsight I recognise that perhaps some of my critics were right.

'I get a great emotional feeling when I look at her, and a sadness when I realise time’s running out. If I could change just one thing, I would wish to be younger so I could enjoy watching Freya grow up, get married and have children of her own. ‘If I’m completely honest, my experience has taught me that 50 should probably be the cut-off limit for having children, but until you have them it’s almost impossible to appreciate that. ‘It’s so true that you only learn by your own mistakes, and my mistake was not to have had her sooner.’

Mrs Tollefsen, a former special needs teacher from Laindon, Essex, gave birth to Freya in 2008. The strain exposed problems that already existed in her relationship with Mr Mayer, and she is now bringing up Freya on her own on a tight income, which includes her pension. Freya stays with her father, a warehouse manager, every other weekend.

‘I’ve never regretted having Freya, but I’ve had to pay a heavy price for my dream of being a mother,’ Mrs Tollefsen added. ‘It’s cost me my relationship. ‘You think you’re madly in love with someone and you just don’t realise what they’re going to be like after you’ve had children.’

Mr Mayer, 49, said: ‘We’re living separately for various reasons. I’d prefer us all to be living together but that’s just not the case – but who knows what’ll happen in the future.’

Mrs Tollefsen also acknowledged the age gap between herself and other mothers at the school gates. ‘They are nice people but we are so different – we are from different generations,’ she said. ‘I have little in common with most of them. They talk about nights out and music and things that just don’t involve me. Sometimes I envy them their youth and infinite chances. I realised, belatedly, that I wanted a sibling for Freya but regretfully I had to devote the time to nursing my parents. But perhaps more than most I now know the real value of the time that’s left to us, and I don’t intend to waste a moment.’

She added: ‘A lot of the criticism I faced was based on my age, with claims that Freya would be abandoned in the event of my death. But Nick is still in his 40s.’ She also lamented the fact that older fathers do not face the sort of criticism she encountered, saying: ‘They get a slap on the back.’ Josephine Quintavalle, a co-founder of the pressure group Comment on Reproductive Ethics, praised Mrs Tollefsen’s candour. ‘One has to admire her honesty in coming forward and speaking frankly about the difficulties about being a mother so old,’ she said. ‘We can only hope that this acts as a warning to others who are in their later years and considering having a child.

‘One has to feel sorry for her, because she took advantage of something society offered her. But I think it shows that we need to have a bit more respect for nature, which seems to know how hard it is to look after a child when you are older. There is a very good reason the menopause comes when it does. IVF and egg-donating are creating a lot of unnatural situations.

‘As a society, we have to start to look at all of these issues from the perspective of the child and ask what is best for them. ‘The ideal situation for a child is to be with a two parents who are young and healthy enough to look after them.’

Article: 7th November 2011 www.dailymail.co.uk