When to give up on IVF treatment?

More than five dozen shots a month, lots of heartbreak, and a devastating miscarriage. That's what E! News host Giuliana Rancic, 36, has endured so far in her quest to become a mother.
Rancic told UsMagazine.com that her IVF fertility treatments include 63 injections per month.

Is there some point at which a couple should be told that enough's enough, and the IVF treatments called off?

"There's no set formula," says Dr. Helen Kim, director of in vitro fertilization at the University of Chicago. "It's very individual, but success does seem to taper off, and if a woman hasn't gotten pregnant after her third cycle, she's certainly less likely to get pregnant with IVF."

In the Rancics' case, which the couple has chronicled on their reality show, "Giuliana & Bill," the miscarriage came after they had been trying to conceive for a year.

Rancic had been eight weeks pregnant when she miscarried back in September.

"Both of us were in shock," Bill, 39, told People magazine. "Failure wasn't an option!"

Giuliana revealed that she was devastated and discouraged by the news. "It's not like some kinds of medicine where there is a definite end point," says Dr. Mark Sauer, professor and chief of reproductive endocrinology at Columbia University, where he also directs the IVF program. "There's an assumption that there is always something you can do for a patient, another treatment. It's hard for doctors to say they just don't know why someone is not getting pregnant."

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