Men suffering from fertility problems have been given renewed hope after a team of scientists were able to grow sperm in a laboratory. In a world's first, scientists have successfully grown mouse sperm in a lab dish and are now hoping they would be able to produce human sperm too.
The team of researchers were led by Professor Stefan Schlatt from Germany’s Muenster University and using just a few cells that are responsible for its production, successfully reproduced mice sperm. They are now hoping they will be able to repeat the technique to produce human sperm, which could then be used in fertility treatments to enable infertile men to father their own children.
Commenting on the research, one Isreali team member, Prof. Mahmoud Huleihel, said: “I believe it will eventually be possible to routinely grow human male sperm to order by extracting tissue containing germ cells from a man’s testicle and stimulating sperm production in the laboratory.” To grow the sperm the scientists wanted to ensure they created conditions that were as similar to those found in the testicles as possible.
As a result, the germ cells were surrounded by agar jelly and grown in an environment with a temperature that was just below the normal body temperature of humans. Professors Schlatt and Huleihel along with their teams are now trying to emulate the results in human sperm “as quickly as possible.”
"We have already applied the same tests as we did with mice in the laboratory, using human cells, but as yet have not had success,” Huleihel noted. “We are confident that if it can be done in a mammal such as a mouse it can be done in humans.”
He added: “We are experimenting with a number of different compounds to get the germ cells to grow into sperm. And we believe it will be possible. And, hopefully, soon.” The work carried out by the research group has received high praise from a number of fertility experts.
One of the UK’s leading fertility scientists, Professor Richard Sharpe, who is based at Edinburgh University, is hoping to get involved with the project in the near future. He said: “This is a significant step forward towards making human sperm.”
Meanwhile, one of the NHS’ top consultants in infertility, Stephen Gordon, added: “This is an amazing development that could revolutionise fertility treatment and allow every man to be a natural father. “Infertile men naturally want to be the father of their child but at present have to accept that can't happen,” he said. “With the mouse discovery, that could now be a possibility.”
The results of the research project have been published in a major scientific journal by Nature. Article: 3rd January 2012 www.healthcareglobal.com
Read more about fertility and sperm donation at www.prideangel.com
Showing posts with label sperm ivf. Show all posts
Showing posts with label sperm ivf. Show all posts
Saturday, 7 January 2012
Saturday, 22 October 2011
Men's fertility declines with age - IVF sudy shows
Men have ticking biological clocks too, as IVF study shows male fertility declines with age - with even a year making a difference, researchers have warned.
They say that after the age of 41, a man’s odds of fathering a child decline rapidly. And after 45, those who haven’t started a family and want one should start doing something about it.
But with the likes of Des O’Connor having his fifth child at 72, and Rod Stewart becoming father for the eighth time at the age of 66, other experts said the finding should be taken with a pinch of salt.
The warning comes from a study of IVF patients in which the man’s sperm fertilised an egg from a donor. In the context of the study, the use of donor eggs allowed the researchers to separate out the effect of the man’s age from that of the woman’s.
The donor eggs all came from young, healthy women and so any differences in pregnancy rate must be due to the sperm. And the difference was clear, with fertility declining by up to seven per cent with each extra year on a man’s age between 41 and 45. After that, it declined even more rapidly.
The average age of the men whose partners got treatment through IVF was 41. But the average age of those in which the IVF was unsuccessful was 45, the American Society for Reproductive Medicine’s annual conference heard. The chances of pregnancy fell from 60 per cent at the age of 41 to just 35 per cent for the 45-year-olds.
Researcher Paula Fettback, of the Huntington Medicina Reproductiva clinic in Brazil, said: ‘Age counts ‘Men have a biological clock too. It is not the same as for women but they can’ t wait forever to have children. ‘They have to think about having children, especially after 45.’
A second study presented at the conference backed up the warning. There, fertility plummeted in male mice from a year old – equivalent to middle-age in people. Fewer eggs were fertilised and fewer embryos grew long enough to be used in IVF.
Pregnancies took longer to occur and when they did, the miscarriage rate rocketed from zero using sperm from young animals, to over 60 per cent. The researchers, from the Colorado Center for Reproductive Medicine, said they believed there would be ‘some parallel’ with men.
‘We found an abrupt reproductive deterioration in mid-life, equivalent to humans in their 40s.’ Other studies have found that children of older fathers also run an increased risk of heart defects, autism, schizophrenia and epilepsy, and are almost twice as likely to die before adulthood.
While men constantly make fresh sperm, the ‘machinery’ that makes it can slow down and become defective over time. In addition, genetic errors may creep into sperm as men get older. But other experts said advised would-be fathers not to worry.
Dr Richard Sherbahn, of the Advanced Fertility Center of Chicago, said that while it is likely that male fertility does decline, any difference is likely to be just a few per cent over decades. He added that IVF can compensate for many problems in sperm, in a way that it can’t with eggs.
Charles Kingsland, a consultant gynaecologist at the Liverpool Women’s Hospital and member of the British Fertility Society, questioned the quality of the study and added that the quality of a woman’s eggs is far more important. He advised men who want to stay in good reproductive shape to eat healthily, not smoke, drink only in moderation, keep active and avoid hot baths, as sperm likes cool temperatures.
He added: ‘There are a lot of advantages to being a young father. First and foremost, you’ve got energy. But being an older father also confers certain advantages – stability, wisdom, maybe a bit of financial security but you don’t have the energy. ‘I wouldn’t go rushing off to procreate on the basis that tomorrow my fertility might drop.’
Article: 20th October 2010 www.dailymail.co.uk
They say that after the age of 41, a man’s odds of fathering a child decline rapidly. And after 45, those who haven’t started a family and want one should start doing something about it.
But with the likes of Des O’Connor having his fifth child at 72, and Rod Stewart becoming father for the eighth time at the age of 66, other experts said the finding should be taken with a pinch of salt.
The warning comes from a study of IVF patients in which the man’s sperm fertilised an egg from a donor. In the context of the study, the use of donor eggs allowed the researchers to separate out the effect of the man’s age from that of the woman’s.
The donor eggs all came from young, healthy women and so any differences in pregnancy rate must be due to the sperm. And the difference was clear, with fertility declining by up to seven per cent with each extra year on a man’s age between 41 and 45. After that, it declined even more rapidly.
The average age of the men whose partners got treatment through IVF was 41. But the average age of those in which the IVF was unsuccessful was 45, the American Society for Reproductive Medicine’s annual conference heard. The chances of pregnancy fell from 60 per cent at the age of 41 to just 35 per cent for the 45-year-olds.
Researcher Paula Fettback, of the Huntington Medicina Reproductiva clinic in Brazil, said: ‘Age counts ‘Men have a biological clock too. It is not the same as for women but they can’ t wait forever to have children. ‘They have to think about having children, especially after 45.’
A second study presented at the conference backed up the warning. There, fertility plummeted in male mice from a year old – equivalent to middle-age in people. Fewer eggs were fertilised and fewer embryos grew long enough to be used in IVF.
Pregnancies took longer to occur and when they did, the miscarriage rate rocketed from zero using sperm from young animals, to over 60 per cent. The researchers, from the Colorado Center for Reproductive Medicine, said they believed there would be ‘some parallel’ with men.
‘We found an abrupt reproductive deterioration in mid-life, equivalent to humans in their 40s.’ Other studies have found that children of older fathers also run an increased risk of heart defects, autism, schizophrenia and epilepsy, and are almost twice as likely to die before adulthood.
While men constantly make fresh sperm, the ‘machinery’ that makes it can slow down and become defective over time. In addition, genetic errors may creep into sperm as men get older. But other experts said advised would-be fathers not to worry.
Dr Richard Sherbahn, of the Advanced Fertility Center of Chicago, said that while it is likely that male fertility does decline, any difference is likely to be just a few per cent over decades. He added that IVF can compensate for many problems in sperm, in a way that it can’t with eggs.
Charles Kingsland, a consultant gynaecologist at the Liverpool Women’s Hospital and member of the British Fertility Society, questioned the quality of the study and added that the quality of a woman’s eggs is far more important. He advised men who want to stay in good reproductive shape to eat healthily, not smoke, drink only in moderation, keep active and avoid hot baths, as sperm likes cool temperatures.
He added: ‘There are a lot of advantages to being a young father. First and foremost, you’ve got energy. But being an older father also confers certain advantages – stability, wisdom, maybe a bit of financial security but you don’t have the energy. ‘I wouldn’t go rushing off to procreate on the basis that tomorrow my fertility might drop.’
Article: 20th October 2010 www.dailymail.co.uk
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