Showing posts with label infertility in men. Show all posts
Showing posts with label infertility in men. Show all posts
Thursday, 20 February 2014
Understanding male infertility | The secret of fertile sperm
To better understand the causes of male infertility, a team of Bay Area researchers is exploring the factors, both physiological and biochemical, that differentiate fertile sperm from infertile sperm. At the 58th Annual Biophysical Society Meeting, which takes place Feb. 15-19, 2014, in San Francisco, Calif., the team will present its work to identify and characterize proteins known as ion channels, which are crucial for sperm fertility and expressed within a sperm cell's plasma membrane.
"Any knowledge gained in this area may help create much-needed diagnostic testing and treatments for male infertility, which is in essence an idiopathic disease, because at this time 80 percent of male infertility cases can't be diagnosed or treated," said Melissa Miller, a postdoctoral fellow who will present the team's findings at the meeting. Miller works in the labs of both of her co-authors, Polina Lishko of the University of California, Berkeley (UCB), and Yuriy Kirichok at the University of California, San Francisco (UCSF).
To study ion channels, the researchers are recording the electrical activity of sperm ion channels under strictly controlled conditions.
"Our labs have characterized three ion channels responsible for regulating calcium (CatSper), potassium (Slo1), and protons (Hv1) within sperm cells," Miller said. "So far, the most well-studied is the sperm cation channel CatSper, which is exclusively expressed within sperm cells and represents an ideal target for development of a unisex contraceptive; no other cell in the body is known to express this protein."
Read more ...
Article: 19th February 2014 www.sciencedaily.com
Monday, 29 November 2010
Low sperm counts making it harder for couples to conceive
Low sperm counts and reduced male fertility may be making it even harder for couples to conceive and be contributing to low birth rates in many countries, reveals a new European Science Foundation (ESF) report launching at a meeting in Paris.
More than 10% of couples worldwide are infertile, contributing to the growing demand for assisted reproduction techniques such as in vitro fertilisation (IVF) for which Robert G. Edwards won the Nobel Prize in Medicine last month.
Sperm counts have dropped significantly in the last 50 years in developed countries. Today, at least one in five 18-25 year old men in Europe have semen quality in subfertile range. Testosterone levels are also declining. This is mirrored by increasing testicular cancer in most industrialised countries and more developmental abnormalities such as undescended testes. All of these factors are linked to reduced fertility and may have common origins during foetal development.
“The important impact of men’s reproductive health on a couple’s fertility is often overlooked,” said Professor Niels Skakkebæk from the University of Copenhagen, who co-authored the report. “Women postponing motherhood have reduced fertility, and we now see that poor sperm may be making it even harder to conceive. While poor sperm may be part of the reason more couples are using IVF it may also be making those therapies less successful.”
Skakkebæk continues: “We need a common strategy in Europe to target research so we can address the poor state of men’s reproductive health. That this decrease in male reproductive health has occurred in just a few decades suggests it’s caused by environmental and lifestyle factors rather than genetics. So it is preventable if we correctly identify the causes.”
In men some lifestyle factors such as obesity and smoking can affect sperm counts, but the effects are small. In contrast, if women smoke heavily in pregnancy, a much larger fall in sperm count is likely in their sons when they grow up. Testosterone levels naturally drop as men age, which may predispose men to cardiovascular and metabolic health problems that pose large financial and healthcare issues for national governments. Low sperm counts and low testosterone levels are both associated with increased risk of early death for men.
To read more go to http://bit.ly/dUnZKH
More than 10% of couples worldwide are infertile, contributing to the growing demand for assisted reproduction techniques such as in vitro fertilisation (IVF) for which Robert G. Edwards won the Nobel Prize in Medicine last month.
Sperm counts have dropped significantly in the last 50 years in developed countries. Today, at least one in five 18-25 year old men in Europe have semen quality in subfertile range. Testosterone levels are also declining. This is mirrored by increasing testicular cancer in most industrialised countries and more developmental abnormalities such as undescended testes. All of these factors are linked to reduced fertility and may have common origins during foetal development.
“The important impact of men’s reproductive health on a couple’s fertility is often overlooked,” said Professor Niels Skakkebæk from the University of Copenhagen, who co-authored the report. “Women postponing motherhood have reduced fertility, and we now see that poor sperm may be making it even harder to conceive. While poor sperm may be part of the reason more couples are using IVF it may also be making those therapies less successful.”
Skakkebæk continues: “We need a common strategy in Europe to target research so we can address the poor state of men’s reproductive health. That this decrease in male reproductive health has occurred in just a few decades suggests it’s caused by environmental and lifestyle factors rather than genetics. So it is preventable if we correctly identify the causes.”
In men some lifestyle factors such as obesity and smoking can affect sperm counts, but the effects are small. In contrast, if women smoke heavily in pregnancy, a much larger fall in sperm count is likely in their sons when they grow up. Testosterone levels naturally drop as men age, which may predispose men to cardiovascular and metabolic health problems that pose large financial and healthcare issues for national governments. Low sperm counts and low testosterone levels are both associated with increased risk of early death for men.
To read more go to http://bit.ly/dUnZKH
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